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The whole physique clearance of sildenafil is 41 l/h with a resultant terminal part half life of 3-5 h. The N-desmethyl metabolite is additional metabolised, with a terminal half life of approximately 4 h. There was no impact on sperm motility or morphology after single 100mg oral doses of sildenafil in healthy volunteers (see section 4.6).. The postulated mechanism for this alteration in color discrimination is expounded to inhibition of PDE6, which is concerned in the phototransduction cascade of the retina. Single oral doses of sildenafil as much as 100mg in healthy volunteers produced no clinically relevant effects on ECG. In a separate RigiScan examine, sildenafil was still capable of produce an erection in response to sexual stimulation 4-5 hours post-dose.
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